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Protein Aggregation and Emerging Analytical Tools 2019

Thu, January 17 - Fri, January 18, 2019 San Diego, California
Hilton San Diego Bayfront 1 Park Blvd San Diego, California 92101 United States +1 619-564-3333

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About Protein Aggregation and Emerging Analytical Tools 2019

PROTEIN AGGREGATION AND EMERGING ANALYTICAL TOOLS, SAN DIEGO, JANUARY 17-18, 2019

The popular 10th Annual Protein Aggregation and Emerging Analytical Tools conference covers latest trends, challenges and solutions in understanding, characterization and mitigation of problems generated by protein aggregation in biopharmaceuticals. This conference will feature in-depth case studies, new and unpublished data and interactive discussions on immunogenicity of aggregates, mechanisms of aggregation, new tools for detection and quantitation of aggregates, and how the data is used in regulatory filings. It will also discuss mechanistic understanding of protein aggregation and present case studies on prevention of particle formation by engineering and formulation approaches, aggregation in ADCs, bispecifics, impact of aggregation on production, aggregates as a factor for immunogenicity, and approaches for improvement of biophysical properties of protein solutions.

Chemical modifications can play an important role in the immunogenicity of proteins. We have designed experiments to test whether specific chemical protein modifications induced by light are immunogenic. Peptides derived from a light-exposed humanized monoclonal antibody were fractionated, and these fractions injected into transgenic mice designed to tolerate native human IgG. Specific peptide fractions showed immunogenic responses, and chemical modifications present in these fractions were characterized by HPLC-MS/MS analysis.

Administration of biotherapeutic drug may be considered: 1) to introduce/supplement a deficit in a natural (self) protein/glycoprotein (P/GP); 2) to manipulate/eliminate the activity of a self-molecule/cell. Clinical experience shows that a proportion of patients produce an anti-therapeutic antibody drug (ATA) immune response. This may be due to: 1) absence of the natural molecule or exposure to an unmatched polymorphic variant; 2) exposure to a molecule lacking structural fidelity with a self P/GP.

About Protein Aggregation and Emerging Analytical Tools 2018

PROTEIN AGGREGATION AND EMERGING ANALYTICAL TOOLS, SAN DIEGO, JANUARY 11-12, 2018

The popular Protein Aggregation and Emerging Analytical Tools conference covers latest trends, challenges and solutions in understanding, characterization and mitigation of problems generated by protein aggregation in biopharmaceuticals. This conference will feature in-depth case studies, new and unpublished data and interactive discussions on mechanisms of aggregation, new tools for detection and quantitation of aggregates, and how the data is used in regulatory filings. It will also discuss mechanistic understanding of protein aggregation and present case studies on prevention of particle formation by engineering and formulation approaches, aggregation in ADCs, bipecifics, impact of aggregation on production, aggregates as a factor for immunogenicity, and approaches for improvement of biophysical properties of protein solutions.

We invite you to present a poster and attend to join with colleagues from around the world in this discussion of the key challenges and solutions in protein aggregation in biotherapeutics.

This event will take place at Hilton San Diego Bayfront, 1 Park Blvd, San Diego, California.

Event Highlights:

  • Mechanism, prediction and overcoming protein aggregation
  • New tools and strategies for hts screening
  • Formulation, process and manufacturing strategies to overcome aggregation
  • Immunogenicity, developability, excipients, and stability

About 7th Annual Protein Aggregation and Emerging Analytical Tools 2016

The popular Protein Aggregation and Emerging Analytical Tools conference covers latest trends, challenges and solutions in understanding, characterization and mitigation of protein aggregation. It features in-depth case studies, new and unpublished data and interactive discussions on mechanisms of aggregation, new tools for detection and quantitation of aggregates, and how the data is used in regulatory filings. It also discusses mechanistic understanding of protein aggregation and present case studies on prevention of particle formation by engineering and formulation approaches, impact of aggregation on production, aggregates as a factor for immunogenicity, and approaches for improvement of biophysical properties of protein solutions. We are looking for cutting-edge research findings and unpublished data to be featured at this forum.

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