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Enhancing Antibody Binding and Specificity 2018 San Diego

Tue, January 9 - Wed, January 10, 2018 San Diego, California
Hilton San Diego Bayfront 1 Park Blvd San Diego, California 92101 United States +1 619-564-3333

About Enhancing Antibody Binding and Specificity 2018 San Diego

ENHANCING ANTIBODY BINDING AND SPECIFICITY, SAN DIEGO, JANUARY 09-10, 2018

As the industry expands its repertoire of antibody drug products into new therapeutic areas, product formats and protein constructs, the control of antibody/antigen targeting, binding and specificity will take on a new level of importance for researchers in this field. The second meeting in the Peptalk Protein Engineering & Development pipeline, Cambridge Healthtech Institute’s Fifth Annual Enhancing Antibody Binding and Specificity, presents innovative approaches to the modulation of binding activity for traditional antibodies, new product formats and difficult targets such as transmembrane proteins.

This event will take place at Hilton San Diego Bayfront, 1 Park Blvd, San Diego, California.

Event Highlights:

  • Advances in Targeting and Signaling
  • Analytical Methods
  • Engineering Binding Affinity
  • Optimizing Antigen Specificity

About Enhancing Antibody Binding and Specificity 2018

ENHANCING ANTIBODY BINDING AND SPECIFICITY, SAN DIEGO, JANUARY 08-12, 2018

As the industry expands its repertoire of antibody drug products into new therapeutic areas, product formats and protein constructs, the control of antibody/antigen targeting, binding and specificity will take on a new level of importance for researchers in this field. The second meeting in the Peptalk Protein Engineering & Development pipeline, Cambridge Healthtech Institute’s Fifth Annual Enhancing Antibody Binding and Specificity, presents innovative approaches to the modulation of binding activity for traditional antibodies, new product formats and difficult targets such as transmembrane proteins.

CAR T cells can effectively kill malignant cells but autoimmune toxicity can occur when normal cells express the same targets. This type of on-target off-tumor toxicity can be lessened using affinity-tuned CARs. We developed an in vivo mouse model that expresses human tumor antigens in normal mouse tissue and showed that a low affinity Her2 CAR had a higher therapeutic index compared to its high affinity counterpart.

Ocular delivery of protein therapeutics often requires favorable viscosity properties to support high-concentration formulations. Using structure-based design we generated high-affinity mutants of a backup Fab which exhibited superior viscosity properties but inferior target binding and inhibition as compared to the lead candidate. Two of these mutants, FM1 and FM2, exhibit binding and target inhibition equal or superior to that of the lead molecule, while retaining the superior viscosity profile.

Oncogenic Ras mutants are high-priority anticancer drug targets. However, direct inhibition of Ras mutants with small molecules has been extremely challenging. In this talk, I will introduce the development of cytosol-penetrating antibody that internalizes into the cytosol of living cells and selectively binds to the activated form of oncogenic Ras mutants to block the interactions with effector proteins, thereby exerting in vivo anti-tumor activity in mouse models after systemic administration.

About Enhancing Antibody Binding and Specificity

As the industry expands its repertoire of antibody-drug products into new therapeutic areas, product formats and protein constructs, the control of antibody/antigen targeting, binding and specificity will take on a new level of importance for researchers in this field. The Enhancing Antibody Binding and Specificity conference presents innovative approaches to the modulation of binding activity, mechanism of action and difficult target challenges such as transmembrane proteins and intracellular targeting.

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