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Bispecific Antibody Therapeutics 2019

Thu, January 17 - Fri, January 18, 2019 San Diego, California
Hilton San Diego Bayfront 1 Park Blvd San Diego, California 92101 United States +1 619-564-3333

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About Bispecific Antibody Therapeutics 2019

BISPECIFIC ANTIBODY THERAPEUTICS, SAN DIEGO, JANUARY 17-18, 2019

CHI’s Bispecific Antibody Therapeutics conference explores the challenges of engineering multi-specificity to achieve more effective therapies that bind to at least two molecular targets simultaneously. These next-generation antibody formats are showing efficacy in the efforts to conquer cancer and other diseases by employing breakthrough technologies and engineering brilliance. Case studies will highlight novel engineering approaches that address safety, stability, enhanced targeting, and manufacturability, as the conference examines current developments, and future directions for these promising molecules.

T cell therapeutics have demonstrated a clinical benefit in hematological malignancies and there is early evidence of activity in solid tumors. Analysis of data derived from T cell therapeutics in hematological malignancies will increase the chances of success for similar therapeutics in solid tumors. This presentation will describe key findings from recent trials of T cell therapeutics in hematological malignancies and will relate these findings to approaches for treating solid tumors.

Xencor has applied its XmAb® bispecific technology platform to create multiple novel modalities for T cell derepression and activation. These include dual checkpoint inhibitors such as PD1 x CTLA4 and CTLA4 x LAG3 bispecific antibodies, as well as a PD1 x ICOS bispecific antibody that combines checkpoint blockade and costimulation into a single molecule. Finally, we have utilized our heterodimeric Fc domain to create a novel long-acting IL15/IL15Rɑ-Fc for immunotherapy.

Integrated platforms can be used to mitigate immunogenicity risk and characterize immune responses during the drug design and development stages. ProImmune offers mutational activity mapping for optimal protein design, DC-T/T cell proliferation assays for biologic lead selection/optimization, a Mass Spectrometry assay for characterization of antigen presentation, HLA-peptide binding assays to characterize individual epitopes and undiluted whole blood cytokine storm assays.

About Bispecific Antibody Therapeutics 2018

BISPECIFIC ANTIBODY THERAPEUTICS, SAN DIEGO, JANUARY 11-12, 2018

Cambridge Healthtech Institute’s Bispecific Antibody Therapeutics conference explores the challenges of engineering multi-specificity to achieve more effective therapies that bind to at least two molecular targets simultaneously. These next-generation antibody formats are showing efficacy in the efforts to conquer cancer and other diseases. Case studies will highlight novel engineering approaches that address safety, stability, enhanced targeting, and manufacturability, as the conference examines current developments, and future directions for these promising molecules.

This event will take place at Hilton San Diego Bayfront, 1 Park Blvd, San Diego, California.

Event Highlights:

  • Creating Next-Generation Therapies
  • Fighting Cancer
  • Engineering Improved Properties with Next-Gen Technologies
  • The Rise of Bispecific Antibodies as Drugs
  • Examples of Development Strategies for Next-Generation Therapeutics
  • Tailoring Processing of Amyloid Precursor Protein as a Therapeutic for Alzheimer’s Disease

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